HR6B / UBE2B

ubiquitin-conjugating enzyme E2B

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

HR6B / UBE2B (10)

Publications

No (10)

Tag

6His, C-terminus (2)

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Human Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (4)

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Human HR6B / UBE2B Protein (Recombinant GST, N-terminus) (aa63-152) - LS-G60462

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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HR6B / UBE2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117410

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.1 kDa

Price:

100 µg/$494

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Human HR6B / UBE2B Protein (Recombinant GST) (Full Length) - LS-G30814

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.35 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HR6B / UBE2B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.1 kDa

Price:

20 µg/$1,107

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Human HR6B / UBE2B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79446

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.1 kDa

Price:

20 µg/$150

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Human HR6B / UBE2B Protein (Recombinant His) - LS-G791

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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Human HR6B / UBE2B Protein (Recombinant 6His, C-terminus) (Met1-Ser152) - LS-G139716

Source:

Mammalian Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.3 kDa

Price:

10 µg/$376; 50 µg/$526

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Human HR6B / UBE2B Protein (Recombinant) (Met1-Ser152) - LS-G139715

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.5 kDa

Price:

10 µg/$376; 50 µg/$526

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Human HR6B / UBE2B Protein (Recombinant) (Met1-Ser152) - LS-G39672

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.5kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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Human HR6B / UBE2B Protein (Recombinant 6His, C-terminus) (Met1-Ser152) - LS-G39221

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

18.3kD

Price:

10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157

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