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HR6B / UBE2B
ubiquitin-conjugating enzyme E2B
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
| Gene Name: | ubiquitin-conjugating enzyme E2B |
| Synonyms: | UBE2B, E2 protein, E2-17kDa, HR6B, RAD6B, Ubiquitin carrier protein B, Ubiquitin-protein ligase B, HHR6B, RAD6 homolog B, UBC2 |
| Target Sequences: | NM_003337 NP_003328.1 P63146 |
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