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HPGDS

hematopoietic prostaglandin D synthase

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Gene Name: hematopoietic prostaglandin D synthase
Synonyms: HPGDS, Glutathione S-transferase, GST class-sigma, GSTS1-1, H-PGDS, PGD2, PGDS, GSTS, Prostaglandin-H2 D-isomerase, PTGDS2
Target Sequences: NM_014485 NP_055300.1 O60760

Publications (2)

1
Monocytes and Macrophages Serve as Potent Prostaglandin D 2<sub> Sources during Acute, Non-Allergic Pulmonary Inflammation. Sonja Rittchen , Katharina Jandl , Ilse Lanz, Bernhard Reiter, Nerea Ferreirós, Daniel Kratz, Jörg Lindenmann, Luka Brcic, Thomas Bärnthaler, Reham Atallah, Horst Olschewski , Eva M Sturm, Akos Heinemann. International journal of molecular sciences. 2021 Oct;22:11697. [Full Text Article] [PubMed:34769126] [PMC:PMC8584273] Related Antibodies: LS-B6886.
2
Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Nature neuroscience. Dec;17:1682-92. [Full Text Article] [PubMed:25362470] Related Antibodies: LS-B6886.

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Proteins (6)
Over-Expression Lysate (2)
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HPGDS (6)
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GST (1)
His (1)
Myc-DDK (Flag) (2)
Human (5)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (1)
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Low endotoxin level (2)
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
23.6kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
HPGDS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
23.2 kDa
20 µg/$150
HPGDS Protein - 12.5% SDS-PAGE of human PGDS stained with Coomassie Blue
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Wheat Germ Extract
GST
49.7 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
23.6 kDa
10 µg/$344; 50 µg/$584
HPGDS Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
23.2 kDa
100 µg/$494
HPGDS Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).