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HPGDS

hematopoietic prostaglandin D synthase

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

Gene Name:	hematopoietic prostaglandin D synthase
Synonyms:	HPGDS, Glutathione S-transferase, GST class-sigma, GSTS1-1, H-PGDS, PGD2, PGDS, GSTS, Prostaglandin-H2 D-isomerase, PTGDS2
Target Sequences:	NM_014485 NP_055300.1 O60760

Publications (2)

Monocytes and Macrophages Serve as Potent Prostaglandin D 2<sub> Sources during Acute, Non-Allergic Pulmonary Inflammation. Sonja Rittchen , Katharina Jandl , Ilse Lanz, Bernhard Reiter, Nerea Ferreirós, Daniel Kratz, Jörg Lindenmann, Luka Brcic, Thomas Bärnthaler, Reham Atallah, Horst Olschewski , Eva M Sturm, Akos Heinemann. International journal of molecular sciences. 2021 Oct;22:11697. [Full Text Article] [PubMed:34769126] [PMC:PMC8584273] Related Antibodies: LS-B6886.

Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. Nature neuroscience. Dec;17:1682-92. [Full Text Article] [PubMed:25362470] Related Antibodies: LS-B6886.

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