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HP / Haptoglobin

haptoglobin

HP / Haptoglobin is a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: haptoglobin
Synonyms: HP, Binding peptide, Haptoglobin alpha(1S)-beta, Haptoglobin, beta polypeptide, Haptoglobin, Haptoglobin alpha(2FS)-beta, Haptoglobin, alpha polypeptide, HP2ALPHA2, BP, Zonulin, HPA1S
Target Sequences: NM_005143 NP_005134.1 P00738

Publications (7)

1
Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. White R, Atherly T, Guard B, Rossi G, Wang C, Mosher C, Webb C, Hill S, Ackermann M, Sciabarra P, Allenspach K, Suchodolski J, Jergens AE. Gut microbes. 2017 September;8:451-466. [Full Text Article] [PubMed:28678609] [PMC:PMC5628651] Related Antibodies: LS-C132998.
2
Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease. Atherly T, Rossi G, White R, Seo YJ, Wang C, Ackermann M, Breuer M, Allenspach K, Mochel JP, Jergens AE. PloS one. 2019 December;14:e0226780. [Full Text Article] [PubMed:31887117] [PMC:PMC6936794] Related Antibodies: LS-C132998.
3
Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. Isabelle S Massart, Geneviève Paulissen, Audrey Loumaye, Pascale Lause, Sarah A Pötgens, Morgane M Thibaut, Estelle Balan, Louise Deldicque, Azeddine Atfi, Edouard Louis, Damien Gruson, Laure B Bindels, Marie-Alice Meuwis, Jean-Paul Thissen. Cancers. 2020 October;12: [Full Text Article] [PubMed:33142864] [PMC:PMC7693727] Related Antibodies: LS-C404051.
4
Histamine promotes adhesion of neutrophils by inhibition of autophagy in dairy cows with subacute ruminal acidosis. Kexin Wang, Zhenai Sun, Yunfei Li, Mingchao Liu, Juan J Loor, Qianming Jiang, Guowen Liu, Zhe Wang, Yuxiang Song, Xinwei Li. Journal of dairy science. 2022 September;105:7600-7614. [Full Text Article] [PubMed:35940921]
5
Free fatty acids promote degranulation of azurophil granules in neutrophils by inducing production of NADPH oxidase-derived reactive oxygen species in cows with subclinical ketosis. Yuxiang Song, Shang Jiang, Congyi Li, Juan J Loor, Qianming Jiang, Yuchen Yang, Xiancheng Feng, Siyuan Liu, Jiyuan He, Kexin Wang, Yunfei Li, Cai Zhang, Xiliang Du, Zhe Wang, Xinwei Li, Guowen Liu. Journal of dairy science. 2022 March;105:2473-2486. [Full Text Article] [PubMed:34998570]
6
Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis. Sun L, Pan J, Peng L, Fang L, Zhao X, Sun L, Yang Z, Ran Y. Annals of surgical oncology. 2012 Jul;19:2411-9. [Full Text Article] [PubMed:22219064] Related Antibodies: LS-B32.
7
The extracellular chaperone haptoglobin prevents serum fatty acid-promoted amyloid fibril formation of beta 2-microglobulin, resistance to lysosomal degradation, and cytotoxicity. Sultan A, Raman B, Rao ChM, Tangirala R. The Journal of biological chemistry. 2013 Nov;288:32326-42. [Full Text Article] [PubMed:24078632] [PMC:PMC3820869] Related Antibodies: LS-B32.
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☰ Filters
Products
Proteins (28)
Native (1)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (5)
Recombinant (21)
HP / Haptoglobin (28)
No (28)
6His, C-terminus (2)
6His, N-terminus (2)
GST (1)
His (8)
His, N-Terminal (3)
His-S (1)
His-T7 (5)
Myc-DDK (Flag) (5)
Bovine (2)
Dog (1)
Human (14)
Mouse (2)
Pig (1)
Rabbit (2)
Rat (4)
293T Cells (2)
E. coli (17)
HEK 293 Cells (5)
Human Cells (1)
Mammalian Cells (1)
Wheat Germ Extract (1)
Purified (3)
Low endotoxin level (4)
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His
22.2 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His
19.8 kDa
10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His, N-Terminal
14.6 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
HP / Haptoglobin Protein
Select
E. coli
His
40.6 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His-S
23.1 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His-T7
22.9 kDa
50 µg/$482; 10 µg/$287; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
HP / Haptoglobin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38.45 kDa
100 µg/$494
Select
HEK 293 Cells
His, N-Terminal
~43 kDa
100 µg/$298
Select
HEK 293 Cells
His, N-Terminal
~43 kDa
200 µl/$283
HP / Haptoglobin Protein - 12.5% SDS-PAGE of human HP stained with Coomassie Blue
Select
Wheat Germ Extract
GST
57.8 kDa
10 µg/$479; 25 µg/$670
HP / Haptoglobin Protein
Select
E. coli
His
50 µg/$361; 250 µg/$739; 10 µg/$261
HP / Haptoglobin Protein - Recombinant  Haptoglobin By SDS-PAGE
Select
E. coli
His-T7
32.7 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
HP / Haptoglobin Protein - Recombinant  Haptoglobin Related Protein By SDS-PAGE
Select
E. coli
His-T7
30.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
HP / Haptoglobin Protein - Recombinant  Haptoglobin By SDS-PAGE
Select
E. coli
His-T7
33.0 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His-T7
22.4 kDa
10 µg/$287; 50 µg/$477; 100 µg/$762; 200 µg/$952; 1 mg/$2,083; 500 µg/$1,613; 5 mg/$3,333; 2 mg/$2,272
HP / Haptoglobin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
38.45 kDa
20 µg/$150
HP / Haptoglobin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
45.21 kDa
20 µg/$150
HP / Haptoglobin Protein - Purified recombinant protein HP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
43.3 kDa
20 µg/$1,107
HP / Haptoglobin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.21 kDa
100 µg/$494
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31.4 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.2 kDa
10 µg/$317; 50 µg/$524
Select
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
31.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
15.9&28.3kD
10 µg/$321; 500 µg/$1,585; 1 mg/$2,353
HP / Haptoglobin Protein - Recombinant Haptoglobin By SDS-PAGE
Select
E. coli
His
21.4 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
Viewing 1-25 of 28 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).