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HOXD10
homeobox D10
HOXD10 is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as "rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.
| Gene Name: | homeobox D10 |
| Synonyms: | HOXD10, Homeo box 4D, Homeobox protein Hox-D10, Hox-4.4, Homeobox protein Hox-4E, HOX4, Homeobox D10, HOX4D, HOX4E, Homeo box D10, Homeobox protein Hox-4D |
| Target Sequences: | NM_002148 NP_002139.2 P28358 |
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