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HOXB4 is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Gene Name: | homeobox B4 |
Synonyms: | HOXB4, Homeo box 2F, Homeo box B4, Homeobox protein Hox-2.6, Homeobox protein Hox-B4, Homeobox B4, Homeobox protein Hox-2F, HOX-2.6, HOX2, HOX2F |
Target Sequences: | NM_024015 NP_076920.1 P17483 |
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