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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development.
Gene Name: | homeobox A2 |
Synonyms: | HOXA2, Homeobox protein Hox-1K, Homeo box A2, HOX1K, Homeobox A2, Homeobox protein Hox-A2 |
Target Sequences: | NP_006726.1 O43364 |
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