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HOOK3
hook microtubule-tethering protein 3
Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex.
| Gene Name: | hook microtubule-tethering protein 3 |
| Synonyms: | HOOK3, H-hook3, HHK3, Hook homolog 3 (Drosophila), Protein Hook homolog 3 |
| Target Sequences: | NM_032410 AAK29204.1 Q86VS8 |
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