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HOMER3 / Homer 3
homer homolog 3 (Drosophila)
HOMER3 / Homer 3 is a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
| Gene Name: | homer homolog 3 (Drosophila) |
| Synonyms: | HOMER3, Homer homolog 3 (Drosophila), Homer protein homolog 3, VESL3, HOMER-3 |
| Target Sequences: | NM_004838 NP_004829.3 Q9NSC5 |
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