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HNRPM / HNRNPM

heterogeneous nuclear ribonucleoprotein M

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Multiple alternatively spliced transcript variants are known for this gene but only two transcripts has been isolated.

Gene Name: heterogeneous nuclear ribonucleoprotein M
Synonyms: HNRNPM, CEA receptor, CEAR, HnRNA-binding protein M4, HNRNPM4, HNRPM4, N-acetylglucosamine receptor 1, NAGR1, HnRNP M, HNRPM, HTGR1
Target Sequences: NM_005968 NP_005959.2 P52272

Publications (3)

1
The clinical and prognostic correlation of HRNPM and SLC1A5 in pathogenesis and prognosis in epithelial ovarian cancer. Bjersand K, Seidal T, Sundström-Poromaa I, Åkerud H, Skirnisdottir I. PloS one. 2017 June;12:e0179363. (Human) [Full Text Article] [PubMed:28609484] [PMC:PMC5469483] Related Antibodies: LS-B4384.
2
Two distinct nuclear stress bodies containing different sets of RNA-binding proteins are formed with HSATIII architectural noncoding RNAs upon thermal stress exposure. Mahmoud Khamis Aly, Kensuke Ninomiya, Shungo Adachi, Tohru Natsume, Tetsuro Hirose. Biochemical and biophysical research communications. 2019 August;516:419-423. [Full Text Article] [PubMed:31227213]
3
Small molecule targeting r(UGGAA)n disrupts RNA foci and alleviates disease phenotype in Drosophila model. Tomonori Shibata, Konami Nagano, Morio Ueyama, Kensuke Ninomiya, Tetsuro Hirose, Yoshitaka Nagai, Kinya Ishikawa, Gota Kawai, Kazuhiko Nakatani. Nature communications. 2021 January;12:236. [Full Text Article] [PubMed:33431896] [PMC:PMC7801683]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).