HnRNP U

heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)

HnRNP U belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

HnRNP U (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Human HnRNP U Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65894

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.8 kDa

Price:

20 µg/$1,107

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Human HnRNP U Protein (Recombinant GST, N-terminus) (aa352-460) - LS-G58860

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HnRNP U Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76474

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.8 kDa

Price:

20 µg/$150

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HnRNP U Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100315

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.8 kDa

Price:

100 µg/$494

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