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Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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HnRNP-E1 / PCBP1
poly(rC) binding protein 1
This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.
| Gene Name: | poly(rC) binding protein 1 |
| Synonyms: | PCBP1, Alpha-CP1, HnRNP E1, HnRNP-E1, HnRNP-X, HNRPE1, Poly(rC) binding protein 1, HNRPX, Poly(rC)-binding protein 1 |
| Target Sequences: | NM_006196 NP_006187.2 Q15365 |
![HnRNP-E1 / PCBP1 Antibody - Immunofluorescence of monoclonal antibody to PCBP1 on HeLa cell . [antibody concentration 10 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/hnrnp-e1-pcbp1-antibody-clone-1g2-ls-c197850/145939_5029363.jpg)
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