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HNP-4 / DEFA4

defensin, alpha 4, corticostatin

Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production.

Gene Name: defensin, alpha 4, corticostatin
Synonyms: DEFA4, DEF4, Corticostatin, HNP-4, HP-4, HP4, Defensin, alpha 4, Neutrophil defensin 4
Target Sequences: NM_001925 NP_001916.1 P12838

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Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
HNP-4 / DEFA4 (4)
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His-GST (2)
Myc-DDK (Flag) (2)
Human (2)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
HNP-4 / DEFA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
10.5 kDa
20 µg/$150
HNP-4 / DEFA4 Protein
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E. coli
His-GST
40.6 kDa
50 µg/$427; 10 µg/$279; 200 µg/$852; 100 µg/$682; 1 mg/$1,950; 500 µg/$1,494; 5 mg/$2,983; 2 mg/$2,136
HNP-4 / DEFA4 Protein - Recombinant  Defensin Alpha 4, Corticostatin By SDS-PAGE
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E. coli
His-GST
40.6 kDa
10 µg/$282; 50 µg/$447; 100 µg/$715; 200 µg/$892; 1 mg/$2,005; 500 µg/$1,543; 5 mg/$3,123; 2 mg/$2,192
HNP-4 / DEFA4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
10.5 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).