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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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HNF1B / HNF1 Beta
HNF1 homeobox B
HNF1B / HNF1 Beta is a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | HNF1 homeobox B |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | HNF1B, FJHN, HNF-1B, HNF1 homeobox B, HNF2, HPC11, LF-B3, LFB3, HNF1beta, TCF2, MODY5, VHNF1, HNF-1-beta, HNF1 beta A, Homeoprotein LFB3, TCF-2, Transcription factor 2 |
| Target Sequences: | NM_000458 NP_000449.1 P35680 |
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