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HMGCS2 / HMG-CoA Synthase 2

3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)

HMGCS2 / HMG-CoA Synthase 2 belongs to the HMG-CoA synthase family. It is a mitochondrial enzyme that catalyzes the first reaction of ketogenesis, a metabolic pathway that provides lipid-derived energy for various organs during times of carbohydrate deprivation, such as fasting. Mutations in this gene are associated with HMG-CoA synthase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Synonyms: HMGCS2, HMG-CoA synthase
Target Sequences: NM_005518 NP_005509.1 P54868

Publications (1)

1
Identification of Tmem10 as a novel late-stage oligodendrocytes marker for detecting hypomyelination. Jiang W, Yang W, Yang W, Zhang J, Pang D, Gan L, Luo L, Fan Y, Liu Y, Chen M. International journal of biological sciences. 2014 10:33-42. (WB; Human) [Full Text Article] [PubMed:24391449] [PMC:PMC3879589]

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Antibodies (32)
Proteins (9)
Over-Expression Lysate (4)
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HMGCS2 / HMG-CoA Synthase 2 (41)
Human (24)
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WB (29)
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rabbit (30)
mouse (1)
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monoclonal mc (1)
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Biotin Conjugated (5)
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Purified (1)
HMGCS2 / HMG-CoA Synthase 2 Antibody - Anti-HMGCS2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (aa51-100) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
HMGCS2 / HMG-CoA Synthase 2 Antibody - Anti-HMGCS2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (aa51-100) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$442
HMGCS2 / HMG-CoA Synthase 2 Antibody - Anti-HMGCS2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (aa51-100) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$442
HMGCS2 / HMG-CoA Synthase 2 Antibody - Anti-HMGCS2 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (aa51-100) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$442
HMGCS2 / HMG-CoA Synthase 2 Antibody - Anti-HMGCS2 antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:75.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (aa478-508) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
200 µl/$460
HMGCS2 / HMG-CoA Synthase 2 Antibody - Fetal liver cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
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HMGCS2 / HMG-CoA Synthase 2 Chicken anti-Human Polyclonal (aa271-487) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µg/$772
HMGCS2 / HMG-CoA Synthase 2 Antibody - Immunohistochemistry of paraffin-embedded Human cervical cancer using HMGCS2 Polyclonal Antibody at dilution of 1:40.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse, Rat
WB
HRP Conjugated
100 µl/$342; 200 µl/$398; 500 µl/$585; 1 ml/$722; 2 ml/$959; 5 ml/$1,639
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse, Rat
WB
Biotin Conjugated
100 µl/$321; 200 µl/$369; 500 µl/$527; 1 ml/$611; 2 ml/$842; 5 ml/$1,387
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse, Rat
WB
FITC Conjugated
100 µl/$352; 200 µl/$412; 500 µl/$622; 1 ml/$777; 2 ml/$1,014; 5 ml/$1,765
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (APC) Antibody
Mouse, Rat
WB
APC Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse, Rat
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (Cy3) Antibody
Mouse, Rat
WB
Cy3 Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot; Sample: Recombinant protein.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Mouse Polyclonal (APC, Cy7) Antibody
Mouse, Rat
WB
APC, Cy7 Conjugated
100 µl/$513; 200 µl/$666; 500 µl/$1,175; 1 ml/$1,441; 2 ml/$2,017; 5 ml/$3,781
HMGCS2 / HMG-CoA Synthase 2 Antibody - Immunohistochemistry image at a dilution of 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
HMGCS2 / HMG-CoA Synthase 2 Protein - Recombinant Hydroxymethylglutaryl Coenzyme A Synthase 2, Mitochondrial (HMGCS2) by SDS-PAGE
Select
E. coli
His, N-Terminal
22.3kDa
10 µg/$287; 50 µg/$482; 200 µg/$962; 100 µg/$770; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western Blot analysis of HMGCS2 expression in transfected 293T cell line by HMGCS2 monoclonal antibody (M06), clone 1E9.Lane 1: HMGCS2 transfected lysate(56.6 KDa).Lane 2: Non-transfected lysate.
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HMGCS2 / HMG-CoA Synthase 2 Mouse anti-Human Monoclonal (1E9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$937
Select
HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$937
Select
HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$937
Select
HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
HMGCS2 / HMG-CoA Synthase 2 Antibody - Western blot analysis of extracts of various cell lines, using HMGCS2 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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HMGCS2 / HMG-CoA Synthase 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Viewing 1-25 of 41 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).