HMG-CoA Reductase / HMGCR

3-hydroxy-3-methylglutaryl-CoA reductase

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Products

ELISA Kits (15)

Type

Competitive EIA (1)

Custom (2)

Sandwich (12)

Target

HMG-CoA Reductase / HMGCR (15)

Reactivity

Human (6)

Mouse (3)

Rat (4)

Bovine (1)

Pig (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (14)

Publications

No (14)

Yes (1)

Sample Type

Cell Lysates (2)

Plasma (11)

Serum (11)

Tissue Homogenates (6)

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Mouse HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F32077

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Rat HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F15758

(4.1) Rating

(2) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.625 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Rat HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F36210

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F38082

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.63 - 40 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$771

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Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F11637

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F32591

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F15757

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

Select

Rat HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F22322

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Rat HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F7315

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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Pig HMG-CoA Reductase / HMGCR (Custom ELISA) ELISA Kit - LS-F15755

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Pig

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Bovine HMG-CoA Reductase / HMGCR (Custom ELISA) ELISA Kit - LS-F15759

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F25429

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F26999

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1 - 25 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Mouse HMG-CoA Reductase / HMGCR (Competitive EIA) ELISA Kit - LS-F28419

Type:

Competitive EIA

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

2.5 - 50 µg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$913

Select

Human HMG-CoA Reductase / HMGCR (Sandwich ELISA) ELISA Kit - LS-F52028

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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