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HLA-G

Major Histocompatibility Complex, Class I, G Heavy Chain

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail.

Gene Name: Major Histocompatibility Complex, Class I, G Heavy Chain
Synonyms: HLA-G, HLAG, HLA-6.0, MHC class I antigen G, HLA G antigen
Target Sequences: NM_002127 NP_002118.1 P17693

Publications (5)

1
HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas. Rutten MJ, Dijk F, Savci-Heijink CD, Buist MR, Kenter GG, van de Vijver MJ, Jordanova ES. Journal of immunology research. 2014 2014:274584. (ICC; Human) [Full Text Article] [PubMed:24987709] [PMC:PMC4058481]
2
HLA-G expression and role in advanced-stage classical Hodgkin lymphoma. Caocci G, Greco M, Fanni D, Senes G, Littera R, Lai S, Risso P, Carcassi C, Faa G, La Nasa G. European journal of histochemistry : EJH. 2016 60:2606. (ICC; Human) [Full Text Article] [PubMed:27349312] [PMC:PMC4933823]
3
Study of immune-tolerized cell lines and extracellular vesicles inductive environment promoting continuous expression and secretion of HLA-G from semiallograft immune tolerance during pregnancy. Kyoungshik Cho, Hyejin Kook, Suman Kang, Jangho Lee. Journal of Extracellular Vesicles. 2020 July;9:1795364. [Full Text Article] [PubMed:32944184] [PMC:PMC7480490]
4
Prostaglandin E2 Receptor 4 (EP4) Affects Trophoblast Functions via Activating the cAMP-PKA-pCREB Signaling Pathway at the Maternal-Fetal Interface in Unexplained Recurrent Miscarriage. Lin Peng , Anca Chelariu-Raicu, Yao Ye, Zhi Ma, Huixia Yang, Hellen Ishikawa-Ankerhold, Martina Rahmeh, Sven Mahner, Udo Jeschke , Viktoria von Schönfeldt. International journal of molecular sciences. 2021 Aug;22:9134. [Full Text Article] [PubMed:34502044] [PMC:PMC8430623] Related Antibodies: LS-C204117.
5
The double-sided of human leukocyte antigen-G molecules in type 1 autoimmune hepatitis. Roberto Littera, Andrea Perra, Michela Miglianti, Ignazio S Piras, Stefano Mocci, Sara Lai, Maurizio Melis, Teresa Zolfino, Cinzia Balestrieri, Maria Conti, Giancarlo Serra, Francesco Figorilli, Davide Firinu, Simona Onali, Laura Matta, Carmen Porcu, Francesco Pes, Daniela Fanni, Cristina Manieli, Monica Vacca, Roberto Cusano, Marcello Trucas, Selene Cipri, Stefania Tranquilli, Stefania Rassu, Federica Cannas, Mauro Giovanni Carta, Marta Anna Kowalik, Erika Giuressi, Gavino Faa, Luchino Chessa,. Frontiers in immunology. 2022 November;13:1007647. [Full Text Article] [PubMed:36311782] [PMC:PMC9597675]
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Proteins (8)
Over-Expression Lysate (2)
Recombinant (6)
HLA-G (8)
No (8)
6His, N-terminus (2)
6His-SUMO, N-terminus (1)
GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (7)
293T Cells (1)
E. coli (3)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (4)
HLA-G Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
HLA-G Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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HEK 293 Cells
6His, N-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
HLA-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
38.25 kDa
20 µg/$150
HLA-G Protein - 12.5% SDS-PAGE of human HLA-G stained with Coomassie Blue
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Wheat Germ Extract
GST
63.69 kDa
10 µg/$479; 25 µg/$670
HLA-G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
38.25 kDa
100 µg/$494
HLA-G Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
6His-SUMO, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
HEK 293 Cells
Myc-DDK (Flag)
35.6 kDa
20 µg/$1,107
HLA-G Protein - Recombinant Major Histocompatibility Complex Class I G By SDS-PAGE
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E. coli
His
11.9 kDa
10 µg/$339; 50 µg/$802; 100 µg/$1,214; 200 µg/$1,430; 1 mg/$2,728; 500 µg/$2,223; 5 mg/$5,601; 2 mg/$2,988
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).