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HLA-E

major histocompatibility complex, class I, E heavy chain

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Gene Name: major histocompatibility complex, class I, E heavy chain
Synonyms: HLA-E, EA2.1, HLAE, MHC HLA-E alpha-2.1, MHC HLA-E alpha-1, EA1.2, HLA-6.2, MHC class I antigen E, QA1
Target Sequences: NM_005516 NP_005507.3 P13747

Publications (1)

1
Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques. David Ma, Takayuki Hirose, Grace Lassiter, Hajime Sasaki, Ivy Rosales, Taylor M Coe, Charles G Rickert, Rudy Matheson, Robert B Colvin, Wenning Qin, Yinan Kan, Jacob V Layer, Violette B Paragas, Kathryn Stiede, Katherine C Hall, Michele E Youd, Luis M Queiroz, William F Westlin, Michael Curtis, Luhan Yang, James F Markmann , Tatsuo Kawai. The Breast : official journal of the European Society of Mastology. 2022 Jan;;22:46-57. [Full Text Article] [PubMed:34331749] Related Antibodies: LS-C179648.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).