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HLA-E

major histocompatibility complex, class I, E heavy chain

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Gene Name: major histocompatibility complex, class I, E heavy chain
Synonyms: HLA-E, EA2.1, HLAE, MHC HLA-E alpha-2.1, MHC HLA-E alpha-1, EA1.2, HLA-6.2, MHC class I antigen E, QA1
Target Sequences: NM_005516 NP_005507.3 P13747

Publications (1)

1
Kidney transplantation from triple-knockout pigs expressing multiple human proteins in cynomolgus macaques. David Ma, Takayuki Hirose, Grace Lassiter, Hajime Sasaki, Ivy Rosales, Taylor M Coe, Charles G Rickert, Rudy Matheson, Robert B Colvin, Wenning Qin, Yinan Kan, Jacob V Layer, Violette B Paragas, Kathryn Stiede, Katherine C Hall, Michele E Youd, Luis M Queiroz, William F Westlin, Michael Curtis, Luhan Yang, James F Markmann , Tatsuo Kawai. The Breast : official journal of the European Society of Mastology. 2022 Jan;;22:46-57. [Full Text Article] [PubMed:34331749] Related Antibodies: LS-C179648.

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Antibodies (62)
Primary (62)
HLA-E (62)
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HLA-E Antibody - Anti-HLA-E antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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HLA-E Mouse anti-Human Monoclonal (MEM-E/02) Antibody
Human, Non-Human Primates
IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
HLA-E Antibody
Select
HLA-E Mouse anti-Human Monoclonal (4D12) Antibody
Human
Flo, IHC, IHC-Fr
Unconjugated
100 µg/$402
HLA-E Antibody
Select
HLA-E Mouse anti-Human Monoclonal (MEM-E/02) Antibody
Human
IHC, WB
Unconjugated
100 µg/$466
HLA-E Antibody - Anti-HLA-E antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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HLA-E Mouse anti-Human Monoclonal (MEM-E/06) Antibody
Human, Non-Human Primates
Flo, IHC, IHC-P, IP
Unconjugated
0.05 mg/$460
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HLA-E Mouse anti-Human Monoclonal (MEM-E/08) Antibody
Human
Flo, IP
Unconjugated
0.1 mg/$330
HLA-E Antibody - Surface staining of HLA-E transfectants with anti-HLA-E (clone MEM-E/07) biotin, streptavidin-APC.
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HLA-E Mouse anti-Human Monoclonal (Biotin) (MEM-E/07) Antibody
Human
Flo, IHC-P, IP
Biotin Conjugated
0.1 mg/$393
HLA-E Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
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HLA-E Mouse anti-Human Monoclonal (Concentrated) (MEM-E/02) Antibody
Human
IHC, IHC-P, WB
Unconjugated, Concentrated
50 µg/$495
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HLA-E Mouse anti-Human Monoclonal (Biotin) (MEM-E/07) Antibody
Human
Flo
Biotin Conjugated
100 µg/$541
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HLA-E Rabbit anti-Human Polyclonal (aa22-305) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
HLA-E Antibody - HLA-E antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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HLA-E Rabbit anti-Human Polyclonal (aa158-207) Antibody
Human
WB
Unconjugated
100 µl/$424
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HLA-E Mouse anti-Human Monoclonal Antibody
Human
Flo, WB
Unconjugated
200 µg/$813
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HLA-E Mouse anti-Human Monoclonal (Azide-free) Antibody
Human
Flo, WB
Unconjugated, Azide-free
100 µg/$649; 200 µg/$1,001
HLA-E Antibody - HLA-E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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HLA-E Mouse anti-Human Monoclonal (MEM-E/06) Antibody
Human, Non-Human Primate
Flo, IHC-P, IP
Unconjugated
100 µg/$447
HLA-E Antibody - HLA-E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
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HLA-E Mouse anti-Human Monoclonal (MEM-E/07) Antibody
Human
Flo, IHC-P, IP
Unconjugated
100 µg/$503
HLA-E Antibody - 1:100 staining human pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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HLA-E Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
HLA-E Mouse anti-Human Monoclonal (Concentrated) (MEM-E/06) Antibody
Human
Flo, IP
Unconjugated, Concentrated
0.1 mg/$526
Select
HLA-E Mouse anti-Human Monoclonal (MEM-E/08) Antibody
Human
Flo, IP
Unconjugated
100 µg/$447
Select
HLA-E Rabbit anti-Human Polyclonal (aa108-135) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
HLA-E Rabbit anti-Human Polyclonal (aa108-135) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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HLA-E Rabbit anti-Human Polyclonal (aa108-135) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
HLA-E Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$351
Select
HLA-E Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
Select
HLA-E Mouse anti-Human Monoclonal (MEM-E/02) Antibody
Human, Non-Human Primate
IHC-P, WB
Unconjugated
100 µg/$541
Select
HLA-E Mouse anti-Human Polyclonal Antibody
Human
Flo, WB
Unconjugated
50 µg/$705
Select
HLA-E Rabbit anti-Human Polyclonal Antibody
Human
IP, WB
Unconjugated
100 µl/$749
Viewing 26-50 of 62 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).