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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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HLA-E

major histocompatibility complex, class I, E heavy chain

HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail.

Gene Name: major histocompatibility complex, class I, E heavy chain
Synonyms: HLA-E, EA2.1, HLAE, MHC HLA-E alpha-2.1, MHC HLA-E alpha-1, EA1.2, HLA-6.2, MHC class I antigen E, QA1
Target Sequences: NM_005516 NP_005507.3 P13747


HLA-E Antibody - Anti-HLA-E antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone MEM-E/07] (IgG1) to Human HLA-E
Human
Flo, IHC, IHC-P, IP
Unconjugated
0.05mg   $425.00
HLA-E Antibody - Surface staining of HLA-E transfectants with anti-HLA-E (clone MEM-E/07) biotin, streptavidin-APC.
Select
Mouse Monoclonal [clone MEM-E/07] (IgG1) to Human HLA-E
Human
Flo, IHC-P, IP
Biotin Conjugated
0.1mg   1mg/ml   $345.00
HLA-E Antibody - Anti-HLA-E antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone MEM-E/02] (IgG1) to Human HLA-E
Human, Non-Human Primates
IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
HLA-E Antibody - Anti-HLA-E antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone MEM-E/06] (IgG1) to Human HLA-E
Human, Non-Human Primates
Flo, IHC, IHC-P, IP
Unconjugated
0.05mg   $425.00
HLA-E Antibody - Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone MEM-E/02] (IgG1) to Human HLA-E
Human
IHC, IHC-P, WB
Unconjugated, Concentrated
50µg   1mg/ml   $505.00
HLA-E Antibody
Select
Mouse Monoclonal [clone 4D12] (IgG1) to Human HLA-E
Human
Flo, IHC, IHC-Fr
Unconjugated
100µg   100µl   1mg/ml   $355.00
Select
Mouse Monoclonal [clone MEM-E/08] (IgG1) to Human HLA-E
Human
Flo, IP
Unconjugated
0.1mg   1mg/ml   $280.00
HLA-E Antibody
Select
Mouse Monoclonal [clone MEM-E/02] (IgG1) to Human HLA-E
Human
IHC, WB
Unconjugated
100µg   1mg/ml   $355.00
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ELISA
Unconjugated
50µg   $285.00; 100µg   2mg/ml   $385.00
HLA-E Antibody - HLA-E antibody Western blot of U937 Cell lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human HLA-E
Human
WB
Unconjugated
100µl   0.5mg/ml   $365.00
HLA-E Antibody - 1:100 staining human pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
HLA-E Antibody - Immunofluorescence staining of HLA-E in A431 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human HLA-E polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm and cell membrane.
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ICC, IF
Unconjugated
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
HLA-E Antibody - HLA-E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Select
Mouse Monoclonal [clone MEM-E/07] (IgG1) to Human HLA-E
Human
Flo, IHC-P, IP
Unconjugated
100µg   $415.00
HLA-E Antibody - HLA-E Antibody in Immunohistochemistry (Paraffin) (IHC (P))
Select
Mouse Monoclonal [clone MEM-E/06] (IgG1) to Human HLA-E
Human, Non-Human Primate
Flo, IHC-P, IP
Unconjugated
100µg   $365.00
Select
Mouse Monoclonal (IgG1) to Human HLA-E
Human
Flo, WB
Unconjugated, Azide-free
100µg   $545.00; 200µg   $1,005.00
Select
Mouse Monoclonal (IgG1) to Human HLA-E
Human
Flo, WB
Unconjugated
200µg   $755.00
Select
Mouse Monoclonal [clone MEM-E/06] (IgG1) to Human HLA-E
Human
Flo, IP
Unconjugated, Concentrated
100µg   $495.00
Select
Mouse Monoclonal [clone MEM-E/08] (IgG1) to Human HLA-E
Human
Flo, IP
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal to Human HLA-E
Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
Select
Rabbit Polyclonal (IgG) to Human HLA-E
Human
ELISA, WB
Unconjugated
100µg   $375.00
Select
Mouse Monoclonal [clone MEM-E/02] (IgG1) to Human HLA-E
Human, Non-Human Primate
IHC-P, WB
Unconjugated
100µg   $445.00
Select
Mouse Polyclonal (IgG) to Human HLA-E
Human
Flo, WB
Unconjugated
50µg   $560.00
Viewing 1-25 of 67 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).