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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HLA-DRB4

major histocompatibility complex, class II, DR beta 4

HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

Gene Name: major histocompatibility complex, class II, DR beta 4
Synonyms: HLA-DRB4, DR-4, DR4, DRB1 transplantation antigen, HLA-DR4B, Human leucocyte antigen DRB4, MHC class2 antigen, MHC class II antigen DRB4, MHC HLA DR-beta chain, DRB4
Target Sequences: NM_021983 NP_068818.4 P13762

Filtered By: None
Target
HLA-DRB4 (16)
Reactivity
Human (16)
Mouse (1)
Application
IHC (5)
IHC-P (2)
WB (16)
ELISA (13)
Host
rabbit (14)
mouse (2)
Isotype
IgG (14)
IgG2b,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (15)
Clone
4C8 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (7)
Epitope
aa43-72 (8)
Publications
No (16)
Showing 1-16 of 16 results

HLA-DRB4 Antibody IHC-plus™ LS-B15742
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $425.00
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.

HLA-DRB4 Antibody (HRP) LS-C377149
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA IHC WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00

HLA-DRB4 Antibody (Biotin) LS-C377145
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA IHC WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00

HLA-DRB4 Antibody (FITC) LS-C377138
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA IHC WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00

HLA-DRB4 Antibody (clone 4C8) LS-C133245
Mouse Monoclonal [clone 4C8] (IgG2b,k) to Human HLA-DRB4
Human
ELISA IHC IHC-P WB
Unconjugated
50µg 0.5mg/ml  $355.00
Immunoperoxidase of monoclonal antibody to HLA-DRB4 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml]
HLA-DRB4 monoclonal antibody (M01), clone 4C8. Western blot of HLA-DRB4 expression in human kidney.
Immunoperoxidase of monoclonal antibody to HLA-DRB4 on formalin-fixed paraffin-embedded human tonsil. [antibody concentration 1 ug/ml]
HLA-DRB4 monoclonal antibody (M01), clone 4C8. Western blot of HLA-DRB4 expression in human kidney.

HLA-DRB4 Antibody (aa43-72) LS-C321994
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
Unconjugated
200µl  $530.00

HLA-DRB4 Antibody (aa43-72, Biotin) LS-C215110
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

HLA-DRB4 Antibody (aa43-72, FITC) LS-C215111
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
FITC Conjugated
200µl  $680.00

HLA-DRB4 Antibody (aa43-72, AP) LS-C215107
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
AP Conjugated
200µl  $680.00

HLA-DRB4 Antibody (aa43-72, PE) LS-C215113
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
PE Conjugated
200µl  $680.00

HLA-DRB4 Antibody (aa43-72, APC) LS-C215109
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
APC Conjugated
200µl  $680.00

HLA-DRB4 Antibody (aa43-72, Azide-free, HRP) LS-C215112
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

HLA-DRB4 Antibody LS-C666153
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Human
ELISA WB
Unconjugated
100µg  $375.00

HLA-DRB4 Antibody (aa43-72) LS-C164921
Rabbit Polyclonal to Human HLA-DRB4
Human
WB
Unconjugated
400µl  $305.00
Western blot of lysate from Raji cell line, using HLA-DRB4 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
Western blot of lysate from Raji cell line, using HLA-DRB4 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

HLA-DRB4 Antibody LS-C496790
Rabbit Polyclonal (IgG) to Human HLA-DRB4
Mouse, Human
WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of various cell lines, using HLA-DRB4 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.
Western blot analysis of extracts of various cell lines, using HLA-DRB4 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 1s.

HLA-DRB4 Antibody LS-C308264
Mouse Polyclonal (IgG) to Human HLA-DRB4
Human
WB
Unconjugated
50µg  $560.00
Showing 1-16 of 16 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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