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Unfortunately, the antibody (ID:150094) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.


major histocompatibility complex, class II, DQ beta 1

Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.

Gene Name: major histocompatibility complex, class II, DQ beta 1
Synonyms: HLA-DQB1, Lymphocyte antigen, MHC class II DQ beta chain, MHC class2 antigen, MHC class II antigen DQB1, HLA-DQB, IDDM1, CELIAC1, MHC DQ beta
Target Sequences: P01920

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Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
HLA-DQB1 Mouse Monoclonal Genox 3.53 Unconjugated Human Flo, ELISA No Primary
Anti-HLA-DQB1 Antibody (clone Genox 3.53) LS-C49047
Mouse Monoclonal [clone Genox 3.53] to Human HLA-DQB1
Flow Cytometry, ELISA
HLA-DQB1 Rabbit Polyclonal Unconjugated Human WB aa13-39 No Primary
Anti-HLA-DQB1 Antibody (aa13-39) LS-C203955
Western blot Image
Rabbit Polyclonal to Human HLA-DQB1
Western blot
HLA-DQB1 Rabbit Polyclonal Unconjugated Human, Monkey, Mouse, Rat, Bovine, Sheep WB Internal No Primary
Anti-HLA-DQB1 Antibody (Internal) LS-C354393
Western blot Image
Rabbit Polyclonal to Human HLA-DQB1
Human, Monkey, Mouse, Rat, Bovine, Sheep
Western blot
HLA-DQB1 Mouse IgG Polyclonal Unconjugated Human WB, Flo No Primary
Anti-HLA-DQB1 Antibody LS-C308260
Mouse Polyclonal (IgG) to Human HLA-DQB1
Western blot, Flow Cytometry
HLA-DQB1 Rabbit IgG Polyclonal Unconjugated Human IP No Primary
Anti-HLA-DQB1 Antibody LS-C311223
Rabbit Polyclonal (IgG) to Human HLA-DQB1
Type Target Reactivity Sample Type
Sandwich HLA-DQB1 Human Cell Lysates, Tissue Homogenates
Human HLA-DQB1 ELISA Kit (Sandwich ELISA) - LS-F9081
Sandwich ELISA (enzyme-linked immunosorbent assay) kit
96-Well Strip Plate with Colorimetric - 450nm detection type
Cell Lysates, Tissue Homogenates
Sandwich HLA-DQB1 Mouse Cell Lysates, Tissue Homogenates
Mouse HLA-DQB1 ELISA Kit (Sandwich ELISA) - LS-F9780
Sandwich ELISA (enzyme-linked immunosorbent assay) kit
96-Well Strip Plate with Colorimetric - 450nm detection type
Cell Lysates, Tissue Homogenates

If you do not find the reagent or information you require, please contact to inquire about additional products in development.


For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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