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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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HLA-DQA1

major histocompatibility complex, class II, DQ alpha 1

HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008]

Gene Name: major histocompatibility complex, class II, DQ alpha 1
Synonyms: HLA-DQA1, DC-alpha, DQ-A1, DC-1 alpha chain, Leukocyte antigen alpha chain, GSE, MHC class II DQA1, HLA-DCA, HLA-DQA, MHC class II antigen, CELIAC1, Leucocyte antigen DQA1, MHC class II HLA-DQ-alpha-1, MHC HLA-DQ alpha
Target Sequences: NM_002122 NP_002113.2 P01909

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HEK 293 Cells
Myc + DDK
27.8 kDa
20µg   $890.00
HLA-DQA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc + DDK
27.8 kDa
20µg   $195.00
HLA-DQA1 Protein
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E. coli
His
25.5 kD
1mg   $1,290.00; 500µg   $830.00; 200µg   $485.00; 50µg   $275.00; 10µg   $245.00; 100µg   $355.00
HLA-DQA1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc + DDK
27.8 kDa
100µg   $365.00

Viewing 1-4 of 4 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).