HLA-C

Major Histocompatibility Complex, Class I, C heavy chain

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described

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Proteins (4)

Type

Recombinant (4)

Target

HLA-C (4)

Publications

No (4)

Tag

6His, N-terminus (1)

GST (1)

His (1)

His, N-terminus (1)

Species

Human (4)

Source

E. coli (3)

Wheat Germ Extract (1)

Purification

Purified (2)

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Human HLA-C Protein (Recombinant His, N-terminus) (aa48-305) - LS-G24636

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

33.2kDa

Price:

10 µg/$299; 50 µg/$552; 100 µg/$882; 200 µg/$1,080; 1 mg/$2,261; 500 µg/$1,775; 5 mg/$3,851; 2 mg/$2,453

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Human HLA-C Protein (Recombinant 6His, N-terminus) (aa25-308) - LS-G22659

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

36.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human HLA-C Protein (Recombinant GST) (Full Length) - LS-G28835

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.2 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HLA-C Protein (Recombinant His) - LS-G2438

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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