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HISPPD2A / VIP1
diphosphoinositol pentakisphosphate kinase 1
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress.
| Gene Name: | diphosphoinositol pentakisphosphate kinase 1 |
| Synonyms: | PPIP5K1, HISPPD2A, IP6 kinase, IP6K, InsP6 and PP-IP5 kinase 1, VIP1, HsVIP1, IPS1, KIAA0377, VIP1 homolog |
| Target Sequences: | NM_014659 NP_055474.3 Q6PFW1 |
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