HIPK3 / FIST

homeodomain interacting protein kinase 3

Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

HIPK3 / FIST (5)

Publications

No (5)

Tag

GST, N-terminus (2)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human HIPK3 / FIST Protein (Recombinant His, N-Terminal) (Met1-Cys264) - LS-G133130

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

33.1kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human HIPK3 / FIST Protein (Recombinant GST, N-terminus) (aa1018-1117) - LS-G61379

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HIPK3 / FIST Protein (Recombinant GST, N-terminus) (aa1-95) - LS-G61381

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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HIPK3 / FIST Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115765

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133.6 kDa

Price:

100 µg/$710

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Human HIPK3 / FIST Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80062

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

133.6 kDa

Price:

20 µg/$215

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