HIPK1

homeodomain interacting protein kinase 1

Serine/threonine-protein kinase involved in transcription regulation and TNF-mediated cellular apoptosis. Plays a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX and MYB. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. Inactivates MYB transcription factor activity by phosphorylation. Prevents MAP3K5-JNK activation in the absence of TNF. TNF triggers its translocation to the cytoplasm in response to stress stimuli, thus activating nuclear MAP3K5-JNK by derepression and promoting apoptosis. May be involved in anti-oxidative stress responses. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. Promotes angiogenesis and to be involved in erythroid differentiation. May be involved in malignant squamous cell tumor formation.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

HIPK1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (4)

Species

Human (5)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human HIPK1 Protein (Recombinant GST, N-terminus) (aa330-430) - LS-G63819

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HIPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88201

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.1 kDa

Price:

20 µg/$150

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Human HIPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88200

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.3 kDa

Price:

20 µg/$150

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Human HIPK1 Protein (Recombinant His-T7) (aa1-290) - LS-G24919

Source:

E. coli

Tag:

His-T7

Molecular Weight:

35.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human HIPK1 Protein (Recombinant GST) (Full Length) - LS-G36989

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

143.2 kDa

Price:

10 µg/$479; 25 µg/$670

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HIPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103762

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

89.3 kDa

Price:

100 µg/$494

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HIPK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104497

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

87.1 kDa

Price:

100 µg/$494

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