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HIP1

huntingtin interacting protein 1

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Gene Name: huntingtin interacting protein 1
Synonyms: HIP1, HIP-1, HIP-I, ILWEQ
Target Sequences: NM_005338 NP_005329.3 O00291

Publications (11)

1
Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Molecular and cellular biology. 2001 21:7796-806. [PubMed:11604514] [PMC:PMC99949]
2
Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. Rao DS, Hyun TS, Kumar PD, Mizukami IF, Rubin MA, Lucas PC, Sanda MG, Ross TS. The Journal of clinical investigation. 2002 110:351-60. [PubMed:12163454] [PMC:PMC151092]
3
HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. Hyun TS, Rao DS, Saint-Dic D, Michael LE, Kumar PD, Bradley SV, Mizukami IF, Oravecz-Wilson KI, Ross TS. The Journal of biological chemistry. 2004 279:14294-306. [PubMed:14732715]
4
Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. Hyun TS, Li L, Oravecz-Wilson KI, Bradley SV, Provot MM, Munaco AJ, Mizukami IF, Sun H, Ross TS. Molecular and cellular biology. 2004 24:4329-40. [PubMed:15121852] [PMC:PMC400480]
5
Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM. The Journal of biological chemistry. 2004 279:46191-203. [PubMed:15292237]
6
Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer. Bradley SV, Oravecz-Wilson KI, Bougeard G, Mizukami I, Li L, Munaco AJ, Sreekumar A, Corradetti MN, Chinnaiyan AM, Sanda MG, Ross TS. Cancer research. 2005 65:4126-33. [PubMed:15899803]
7
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. Mills IG, Gaughan L, Robson C, Ross T, McCracken S, Kelly J, Neal DE. The Journal of cell biology. 2005 170:191-200. (WB; Bacteria) [PubMed:16027218] [PMC:PMC2171420]
8
Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS. Cancer research. 2007 67:3609-15. [PubMed:17440072]
9
Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. Bradley SV, Smith MR, Hyun TS, Lucas PC, Li L, Antonuk D, Joshi I, Jin F, Ross TS. Cancer research. 2007 67:8923-31. [PubMed:17875735]
10
G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Barker BL, Benovic JL. Biochemistry. 2011 50:6933-41. (WB; Human) [PubMed:21728385] [PMC:PMC3156627]
11
Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death. Fontaine SN, Bauer SP, Lin X, Poorfarahani S, Ybe JA. FEBS letters. 2012 586:3030-6. (ICC, WB; Human) [PubMed:22835334]
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Proteins (5)
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HIP1 (5)
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HIP1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HIP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
116.2 kDa
20 µg/$150
HIP1 Protein - 12.5% SDS-PAGE of human HIP1 stained with Coomassie Blue
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GST
142.6 kDa
10 µg/$479; 25 µg/$670
HIP1 Protein - Recombinant Huntingtin Interacting Protein 1 (HIP1) by SDS-PAGE
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E. coli
His, N-Terminal
27.8kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
HIP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
116.2 kDa
100 µg/$494
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).