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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HIP1

huntingtin interacting protein 1

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Gene Name: huntingtin interacting protein 1
Synonyms: HIP1, HIP-1, HIP-I, ILWEQ
Target Sequences: NM_005338 NP_005329.3 O00291

Publications (11)

1
Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Rao DS, Chang JC, Kumar PD, Mizukami I, Smithson GM, Bradley SV, Parlow AF, Ross TS. Molecular and cellular biology. 2001 21:7796-806. [PubMed:11604514] [PMC:PMC99949]
2
Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. Rao DS, Hyun TS, Kumar PD, Mizukami IF, Rubin MA, Lucas PC, Sanda MG, Ross TS. The Journal of clinical investigation. 2002 110:351-60. [PubMed:12163454] [PMC:PMC151092]
3
HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. Hyun TS, Rao DS, Saint-Dic D, Michael LE, Kumar PD, Bradley SV, Mizukami IF, Oravecz-Wilson KI, Ross TS. The Journal of biological chemistry. 2004 279:14294-306. [PubMed:14732715]
4
Hip1-related mutant mice grow and develop normally but have accelerated spinal abnormalities and dwarfism in the absence of HIP1. Hyun TS, Li L, Oravecz-Wilson KI, Bradley SV, Provot MM, Munaco AJ, Mizukami IF, Sun H, Ross TS. Molecular and cellular biology. 2004 24:4329-40. [PubMed:15121852] [PMC:PMC400480]
5
Dual engagement regulation of protein interactions with the AP-2 adaptor alpha appendage. Mishra SK, Hawryluk MJ, Brett TJ, Keyel PA, Dupin AL, Jha A, Heuser JE, Fremont DH, Traub LM. The Journal of biological chemistry. 2004 279:46191-203. [PubMed:15292237]
6
Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer. Bradley SV, Oravecz-Wilson KI, Bougeard G, Mizukami I, Li L, Munaco AJ, Sreekumar A, Corradetti MN, Chinnaiyan AM, Sanda MG, Ross TS. Cancer research. 2005 65:4126-33. [PubMed:15899803]
7
Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. Mills IG, Gaughan L, Robson C, Ross T, McCracken S, Kelly J, Neal DE. The Journal of cell biology. 2005 170:191-200. (WB; Bacteria) [PubMed:16027218] [PMC:PMC2171420]
8
Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. Bradley SV, Holland EC, Liu GY, Thomas D, Hyun TS, Ross TS. Cancer research. 2007 67:3609-15. [PubMed:17440072]
9
Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. Bradley SV, Smith MR, Hyun TS, Lucas PC, Li L, Antonuk D, Joshi I, Jin F, Ross TS. Cancer research. 2007 67:8923-31. [PubMed:17875735]
10
G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Barker BL, Benovic JL. Biochemistry. 2011 50:6933-41. (WB; Human) [PubMed:21728385] [PMC:PMC3156627]
11
Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death. Fontaine SN, Bauer SP, Lin X, Poorfarahani S, Ybe JA. FEBS letters. 2012 586:3030-6. (ICC, WB; Human) [PubMed:22835334]
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Filtered By: None
Target
HIP1 (30)
Reactivity
Human (30)
Mouse (7)
Rat (7)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (8)
Horse (4)
Pig (4)
Rabbit (8)
Application
IHC (10)
IHC-P (4)
WB (29)
ELISA (5)
ICC (1)
IF (5)
IP (3)
Host
rabbit (23)
mouse (7)
Isotype
IgG (13)
IgG1,k (5)
IgG2a,k (1)
Clonality
monoclonal mc (6)
polyclonal pc (24)
Clone
1E1 (1)
1F12 (1)
4B10 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (18)
Epitope
C-Terminus (4)
aa338-387 (4)
aa410-690 (2)
Publications
No (30)
Showing 1-25 of 30 results

HIP1 Antibody (clone 1F12) IHC-plus™ LS-B6765
Mouse Monoclonal [clone 1F12] (IgG2a,k) to Human HIP1
Human
ELISA IHC IHC-P IP WB
Unconjugated
50µg 0.4mg/ml  $485.00
Anti-HIP1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
HIP1 monoclonal antibody, clone 1F12 Western blot of HIP1 expression in HeLa.
Anti-HIP1 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
HIP1 monoclonal antibody, clone 1F12 Western blot of HIP1 expression in HeLa.

HIP1 Antibody IHC-plus™ LS-B14586
Rabbit Polyclonal to Human HIP1
Mouse, Human
ICC IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of HIP1 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Immunofluorescent analysis of HIP1 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.

HIP1 Antibody (clone 1E1) LS-C2686
Mouse Monoclonal [clone 1E1] (IgG1,k) to Human HIP1
Rat, Human
IF IHC IP WB
Unconjugated
100µl  $335.00
Western blot of HIP1 protein in HeLa cell and rat brain lysates, using HIP1 [1E1] antibody.
Western blot of HIP1 protein in HeLa cell and rat brain lysates, using HIP1 [1E1] antibody.

HIP1 Antibody (clone 4B10) LS-C2687
Mouse Monoclonal [clone 4B10] (IgG1,k) to Human HIP1
Human
IF IHC IP WB
Unconjugated
100µl  $335.00
HIP1 Antibody (4B10) - Western Blot on HeLa whole cell extracts.
HIP1 Antibody (4B10) - Western Blot on HeLa whole cell extracts.

HIP1 Antibody (aa410-690) LS-C375894
Rabbit Polyclonal (IgG) to Human HIP1
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human colorectal carcinoma using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human colorectal carcinoma using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human placenta using antibody at 1:100 dilution.

HIP1 Antibody LS-C412602
Rabbit Polyclonal to Human HIP1
Mouse, Human
IF IHC WB
Unconjugated
100µl  $385.00

HIP1 Antibody LS-C346141
Rabbit Polyclonal (IgG) to Human HIP1
Mouse, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded mouse brain tissue.
Western blot analysis of extracts of various cell lines.
Immunohistochemistry of paraffin-embedded mouse brain tissue.
Western blot analysis of extracts of various cell lines.

HIP1 Antibody LS-C666138
Rabbit Polyclonal (IgG) to Human HIP1
Human
ELISA IHC WB
Unconjugated
100µg  $375.00

HIP1 Antibody LS-C752004
Rabbit Polyclonal (IgG) to Human HIP1
Human
ELISA IHC WB
Unconjugated
100µg  $355.00

HIP1 Antibody (aa410-690) LS-C375891
Rabbit Polyclonal (IgG) to Human HIP1
Human
ELISA IHC IHC-P
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.

HIP1 Antibody LS-C68274
Mouse Monoclonal (IgG1,k) to Human HIP1
Human
WB
Unconjugated
100µl  $515.00

HIP1 Antibody LS-C68275
Mouse Monoclonal (IgG1,k) to Human HIP1
Human
WB
Unconjugated
100µl  $515.00

HIP1 Antibody LS-C68276
Mouse Monoclonal (IgG1,k) to Human HIP1
Rat, Human
WB
Unconjugated
100µl  $515.00

HIP1 Antibody LS-C310609
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
Unconjugated
100µg  $605.00

HIP1 Antibody (HRP) LS-C542512
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
HRP Conjugated
100µl  $755.00

HIP1 Antibody (Biotin) LS-C522381
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
Biotin Conjugated
100µl  $755.00

HIP1 Antibody (FITC) LS-C532425
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
FITC Conjugated
100µl  $755.00

HIP1 Antibody (AP) LS-C504457
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
AP Conjugated
100µl  $755.00

HIP1 Antibody (APC) LS-C514166
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
APC Conjugated
100µl  $755.00

HIP1 Antibody (PE) LS-C650626
Rabbit Polyclonal (IgG) to Human HIP1
Human
WB
PE Conjugated
100µl 0.7mg/ml  $755.00

HIP1 Antibody LS-C152863
Rabbit Polyclonal to Human HIP1
Rat, Human
WB
Unconjugated
100µl  $435.00
WB using HIP1 (HIP1, RBX-100UL) on P2 microsomal fraction from embryonic rat brain. Band is at ~116kDa.
WB using HIP1 (HIP1, RBX-100UL) on P2 microsomal fraction from embryonic rat brain. Band is at ~116kDa.

HIP1 Antibody (aa338-387) LS-C206134
Rabbit Polyclonal to Human HIP1
Rabbit, Guinea pig, Human
WB
Unconjugated
50µg  $365.00
HIP1 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
HIP1 antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HIP1 Antibody (C-Terminus) LS-C345605
Rabbit Polyclonal to Human HIP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
WB
Unconjugated
50µg  $365.00
Western blot of HIP1 Antibody with human A549 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of HIP1 Antibody with human A549 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HIP1 Antibody (C-Terminus, FITC) LS-C471182
Rabbit Polyclonal to Human HIP1
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human
WB
FITC Conjugated
100µl 1mg/ml  $385.00
Western blot of HIP1 Antibody with human A549 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Western blot of HIP1 Antibody with human A549 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

HIP1 Antibody LS-C308238
Mouse Polyclonal (IgG) to Human HIP1
Human
WB
Unconjugated
50µg  $560.00
Showing 1-25 of 30 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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