HINT / HINT1

histidine triad nucleotide binding protein 1

Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

HINT / HINT1 (7)

Publications

No (7)

Tag

10His, N-terminus + Myc, C-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Rabbit (1)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Mammalian Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

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HINT / HINT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116035

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.6 kDa

Price:

100 µg/$494

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Human HINT / HINT1 Protein (Recombinant GST) (Full Length) - LS-G28828

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

39.6 kDa

Price:

2 µg/$439

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Human HINT / HINT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76504

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.6 kDa

Price:

20 µg/$150

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Rabbit HINT / HINT1 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) (aa2-126) - LS-G57067

Source:

Mammalian Cells

Tag:

10His, N-terminus + Myc, C-terminus

Price:

100 µg/$1,266; 20 µg/$506; 1 mg/$4,627

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Human HINT / HINT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65911

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

13.6 kDa

Price:

20 µg/$1,107

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Human HINT / HINT1 Protein (Recombinant GST, N-terminus) (aa59-126) - LS-G58835

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human HINT / HINT1 Protein (Recombinant) - LS-G548

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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