HIF1AN

hypoxia inducible factor 1, alpha subunit inhibitor

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

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Products

ELISA Kits (5)

Type

Custom (2)

Sandwich (3)

Target

HIF1AN (5)

Reactivity

Human (4)

Mouse (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (4)

Publications

No (5)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (2)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

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Human HIF1AN (Custom ELISA) ELISA Kit - LS-F14643

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse HIF1AN (Custom ELISA) ELISA Kit - LS-F14644

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human HIF1AN (Sandwich ELISA) ELISA Kit - LS-F36012

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human HIF1AN (Sandwich ELISA) ELISA Kit - LS-F74524

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$642

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Human HIF1AN (Sandwich ELISA) ELISA Kit - LS-F9923

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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