HIC1

hypermethylated in cancer 1

Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1 (indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

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Proteins (2)

Type

Recombinant (2)

Target

HIC1 (2)

Publications

No (2)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (1)

Species

Human (2)

Source

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human HIC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69748

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$1,107

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Human HIC1 Protein (Recombinant GST, N-terminus) (aa627-705) - LS-G58834

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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