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HHLA2

Herv-h Ltr-associating 2

Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Gene Name:	Herv-h Ltr-associating 2
Synonyms:	HHLA2, B7H7, HERV-H LTR-associating 2
Target Sequences:	NM_007072 NP_009003.1 Q9UM44

Publications (1)

Overexpression of HHLA2 in human clear cell renal cell carcinoma is significantly associated with poor survival of the patients. Lujun Chen , Dawei Zhu , Jun Feng , You Zhou, Qi Wang, Huijing Feng, Junping Zhang, Jingting Jiang. Cancer cell international. 2019 Apr;19:101. [Full Text Article] [PubMed:31015801] [PMC:PMC6469208] Related Antibodies: LS-C321945.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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