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HHEX / HEX

hematopoietically expressed homeobox

Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.

Gene Name: hematopoietically expressed homeobox
Synonyms: HHEX, HEX, HMPH, Homeobox protein HEX, HOX11L-PEN, PRHX, Homeobox protein PRH, PRH
Target Sequences: AF132550 AAF04349.1 P43120

Publications (2)

1
The tumor suppressor HHEX inhibits axon growth when prematurely expressed in developing central nervous system neurons. Simpson MT, Venkatesh I, Callif BL, Thiel LK, Coley DM, Winsor KN, Wang Z, Kramer AA, Lerch JK, Blackmore MG. Molecular and cellular neurosciences. 2015 68:272-83. (ELISA; Human) [Full Text Article] [PubMed:26306672] [PMC:PMC4832606]
2
Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701]

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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
HHEX / HEX (5)
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GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
HHEX / HEX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
29.8 kDa
100 µg/$494
HHEX / HEX Protein - 12.5% SDS-PAGE of human HHEX stained with Coomassie Blue
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Wheat Germ Extract
GST
55.44 kDa
10 µg/$479; 25 µg/$670
HHEX / HEX Protein
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E. coli
His
20 µg/$361; 100 µg/$739; 4 µg/$261
HHEX / HEX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
29.8 kDa
20 µg/$150
HHEX / HEX Protein - Purified recombinant protein HHEX was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
29.8 kDa
20 µg/$1,107
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).