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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-ß in gastric tissue. Ota M, Horiguchi M, Fang V, Shibahara K, Kadota K, Loomis C, Cammer M, Rifkin DB. Cancer research. 2014 74:2642-51. (WB; Human)[Full Text Article]
[PubMed:24590056]
[PMC:PMC4158836]
2
Novel MET/TIE2/VEGFR2 inhibitor altiratinib inhibits tumor growth and invasiveness in bevacizumab-resistant glioblastoma mouse models. Piao Y, Park SY, Henry V, Smith BD, Tiao N, Flynn DL, de Groot JF. Neuro-oncology. 2016 September;18:1230-41. (Human)[Full Text Article]
[PubMed:26965451]
[PMC:PMC4998992]
Related Antibodies: LS-B4657.
3
N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals. Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y Zaytseva, Kathleen L O'Connor, Craig W Vander Kooi, Side Liu, Qing-Bai She. Nature communications. 2019 August;10:3708. [Full Text Article]
[PubMed:31420553]
[PMC:PMC6697747]
4
Expression of HGF, pMet, and pAkt is related to benefit of radiotherapy after breast-conserving surgery: a long-term follow-up of the SweBCG91-RT randomised trial. Martin Sjöström, Cynthia Veenstra, Erik Holmberg, Per Karlsson, Fredrika Killander, Per Malmström, Emma Niméus, Mårten Fernö, Olle Stål. Molecular oncology. 2020 September; [Full Text Article]
[PubMed:32946618]
[PMC:PMC7607179]
Related Antibodies: LS-B3265.
5
Impaired integrin a5 /ß1 -mediated hepatocyte growth factor release by stellate cells of the aged liver. Friederike Rohn, Claus Kordes, Tobias Buschmann, Doreen Reichert, Marianne Wammers, Gereon Poschmann, Kai Stühler, Amelie S Benk, Fania Geiger, Joachim P Spatz, Dieter Häussinger. Aging cell. 2020 Apr;19:e13131. [Full Text Article]
[PubMed:32157808]
[PMC:PMC7189994]
Related Antibodies: LS-C486534.
6
Expression of hypoxia-inducible factor-1 alpha and hepatocyte growth factor in development of fibrosis in the transplanted kidney. Kellenberger T, Marcussen N, Nyengaard JR, Wogensen L, Jespersen B. Transplant international : official journal of the European Society for Organ Transplantation. Feb;28:180-90. [Full Text Article]
[PubMed:25284705]
Related Antibodies: LS-B4957.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).