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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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20700 44th Avenue W
Lynnwood, WA 98036
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HERC2
HECT and RLD domain containing E3 ubiquitin protein ligase 2
E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.
| Gene Name: | HECT and RLD domain containing E3 ubiquitin protein ligase 2 |
| Synonyms: | HERC2, D15F37S1, Hect domain and RLD 2, Jdf2, p528, SHEP1 |
| Target Sequences: | NM_004667 NP_004658.3 O95714 |
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