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Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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HDS / DHDDS
dehydrodolichyl diphosphate synthase
With DHDDS, forms the dehydrodolichyl diphosphate syntase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precusrosor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol.
| Gene Name: | dehydrodolichyl diphosphate synthase |
| Synonyms: | DHDDS, Cis-IPTase, Cis-isoprenyltransferase, Dedol-PP synthase, CPT, Cis-prenyl transferase, DS, HDS, RP59 |
| Target Sequences: | NM_024887 NP_079163.2 Q86SQ9 |
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