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HDAC3

histone deacetylase 3

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Gene Name: histone deacetylase 3
Family/Subfamily: Histone Deacetylase , not assigned-Histone Deacetylase
Synonyms: HDAC3, RPD3, SMAP45, HD3, Histone deacetylase 3, RPD3-2
Target Sequences: NM_003883 NP_003874.2 O15379

Publications (2)

1
Large-cell neuroendocrine carcinoma of the ampulla of Vater. Stojsic Z, Brasanac D, Bilanovic D, Mitrovic O, Stevanovic R, Boricic I. Medical oncology (Northwood, London, England). 2010 27:1144-8. (IHC) [PubMed:19898974]
2
Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Motoyama S, Ogawa J. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2010 31:533-9. (IHC) [PubMed:20563766]

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HDAC3 ELISA Kit
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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HDAC3 ELISA Kit
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$579
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96-Well Microplate
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Colorimetric - 450nm (TMB)
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1 Plate/$618
HDAC3 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).