HDAC1

histone deacetylase 1

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

HDAC1 (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

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Purified (1)

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Human HDAC1 Protein (Recombinant His-SUMO) (Full Length) - LS-G20812

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

71.1 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human HDAC1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65916

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.9 kDa

Price:

20 µg/$1,107

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Human HDAC1 Protein (Recombinant GST, N-terminus) (aa28-137) - LS-G58829

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HDAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76520

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.9 kDa

Price:

20 µg/$150

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Human HDAC1 Protein (Recombinant GST) (Full Length) - LS-G28809

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.76 kDa

Price:

10 µg/$479; 25 µg/$670

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HDAC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116286

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.9 kDa

Price:

100 µg/$494

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