HCF1 / HCFC1

host cell factor C1 (VP16-accessory protein)

Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.

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Products

Proteins (4)

Type

Recombinant (4)

Target

HCF1 / HCFC1 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Species

Human (3)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human HCF1 / HCFC1 Protein (Recombinant GST, N-terminus) (aa568-654) - LS-G58823

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human HCF1 / HCFC1 Protein (Recombinant His-T7) (aa52-258) - LS-G24691

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.7 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Mouse HCF1 / HCFC1 Protein (Recombinant His-T7) (aa107-332) - LS-G24692

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.9 kDa

Price:

10 µg/$270; 50 µg/$372; 100 µg/$592; 200 µg/$742; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966

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Human HCF1 / HCFC1 Protein (Recombinant GST) (Full Length) - LS-G28805

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.6 kDa

Price:

2 µg/$439

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