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HBB / Hemoglobin Beta

hemoglobin, beta

The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin that sickles causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Gene Name:	hemoglobin, beta
Synonyms:	HBB, CD113t-C, Hemoglobin beta, Hemoglobin beta chain, Hemoglobin subunit beta, Beta globin chain, Beta-globin, Hemoglobin, beta
Target Sequences:	NM_000518 NP_000509.1 P68871

Publications (1)

Iron imaging in myocardial infarction reperfusion injury. Brianna F Moon, Srikant Kamesh Iyer, Eileen Hwuang, Michael P Solomon, Anya T Hall, Rishabh Kumar, Nicholas J Josselyn, Elizabeth M Higbee-Dempsey, Andrew Tsourkas, Akito Imai, Keitaro Okamoto, Yoshiaki Saito, James J Pilla, Joseph H Gorman rd, Robert C Gorman, Cory Tschabrunn, Samuel J Keeney, Estibaliz Castillero, Giovanni Ferrari, Steffen Jockusch, Felix W Wehrli, Haochang Shou, Victor A Ferrari, Yuchi Han, Avanti Gulhane, Harold Litt, William Matthai, Walter R Witschey. Nature communications. 2020 June;11:3273. [Full Text Article] [PubMed:32601301] [PMC:PMC7324567] Related Antibodies: LS-C755633.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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