HAS1 / HAS

Hyaluronan Synthase 1

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

HAS1 / HAS (5)

Publications

No (5)

Tag

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (2)

Species

Human (2)

Rat (2)

Source

293T Cells (1)

E. coli (2)

Eukaryotic cells (1)

HEK 293 Cells (1)

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Rat HAS1 / HAS Protein (Recombinant His) (aa164-421) - LS-G14964

Source:

E. coli

Tag:

His

Molecular Weight:

31.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human HAS1 / HAS Protein (Recombinant His, N-Terminal) (Ser96-Trp394) - LS-G133025

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

38.2kDa

Price:

10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human HAS1 / HAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80997

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.7 kDa

Price:

20 µg/$150

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Rat HAS1 / HAS Protein (Recombinant His, N-Terminal) (Met1-Val583) - LS-G133091

Source:

Eukaryotic cells

Tag:

His, N-Terminal

Molecular Weight:

67.8kDa

Price:

10 µg/$307; 50 µg/$602; 200 µg/$1,156; 100 µg/$962; 1 mg/$2,369; 500 µg/$1,876; 5 mg/$4,801

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HAS1 / HAS Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118534

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

64.7 kDa

Price:

100 µg/$494

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