HAS1 / HAS

Hyaluronan Synthase 1

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase. Alternative splicing results in multiple transcript variants.

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Antibodies (30)

Proteins (5)

ELISA Kits (4)

Type

Custom (2)

Over-Expression Lysate (2)

Primary (30)

Recombinant (3)

Sandwich (2)

Target

HAS1 / HAS (39)

Reactivity

Human (25)

Mouse (7)

Rat (12)

Bovine (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Monkey (3)

Pig (3)

Application

IHC (2)

IHC-P (2)

WB (24)

ELISA (10)

ICC (1)

IF (4)

Host

rabbit (27)

mouse (3)

Isotype

IgG (14)

IgG1 (3)

Clonality

monoclonal mc (3)

polyclonal pc (27)

Clone

30000000000 (1)

3E10 (1)

Format

96-Well Strip Plate (4)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (2)

Unconjugated (12)

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Epitope

aa164-421 (8)

aa166-193 (7)

aa171-220 (4)

Publications

No (39)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (2)

Tag

His (1)

His, N-Terminal (2)

Myc-DDK (Flag) (2)

Species

Human (2)

Rat (2)

Source

293T Cells (1)

E. coli (2)

Eukaryotic cells (1)

HEK 293 Cells (1)

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Human HAS1 / HAS (Sandwich ELISA) ELISA Kit - LS-F8228

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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Rat HAS1 / HAS Protein (Recombinant His) (aa164-421) - LS-G14964

Source:

E. coli

Tag:

His

Molecular Weight:

31.4 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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HAS1 / HAS Antibody LS-C782264

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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HAS1 / HAS Antibody (clone 3E10) LS-C169231

Antibody:

HAS1 / HAS Mouse anti-Human Monoclonal (3E10) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$435

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HAS1 / HAS Antibody LS-C812636

Antibody:

HAS1 / HAS Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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HAS1 / HAS Antibody (aa166-193) LS-C166791

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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HAS1 / HAS Antibody (clone 30000000000) LS-C758861

Antibody:

HAS1 / HAS Mouse anti-Human Monoclonal (30000000000) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$541

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Human HAS1 / HAS (Sandwich ELISA) ELISA Kit - LS-F34994

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human HAS1 / HAS Protein (Recombinant His, N-Terminal) (Ser96-Trp394) - LS-G133025

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

38.2kDa

Price:

10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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HAS1 / HAS Antibody LS-C671809

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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HAS1 / HAS Antibody (FITC) LS-C671807

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• FITC

• Unconjugated
• FITC

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HAS1 / HAS Antibody LS-C831068

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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HAS1 / HAS Antibody (aa166-193) LS-C321874

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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HAS1 / HAS Antibody (aa166-193, Biotin) LS-C258248

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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HAS1 / HAS Antibody (aa166-193, FITC) LS-C258249

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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HAS1 / HAS Antibody (aa166-193, APC) LS-C258247

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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HAS1 / HAS Antibody (aa166-193, PE) LS-C258251

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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HAS1 / HAS Antibody (aa166-193, Azide-free, HRP) LS-C258250

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa166-193) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

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HAS1 / HAS Antibody (aa171-220) LS-C151522

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa171-220) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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HAS1 / HAS Antibody (aa171-220, HRP) LS-C470877

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa171-220) (HRP) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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HAS1 / HAS Antibody (aa171-220, Biotin) LS-C470875

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa171-220) (Biotin) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

HAS1 / HAS Antibody (aa171-220, FITC) LS-C470876

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal (aa171-220) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

HAS1 / HAS Antibody LS-C497162

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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HAS1 / HAS Antibody LS-C816488

Antibody:

HAS1 / HAS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µl/$412

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HAS1 / HAS Antibody (aa164-421) LS-C294540

Antibody:

HAS1 / HAS Rabbit anti-Rat Polyclonal (aa164-421) Antibody

Reactivity:

Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331

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