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HAMP / Hepcidin

hepcidin antimicrobial peptide

Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).

Gene Name: hepcidin antimicrobial peptide
Synonyms: HAMP, Hepcidin antimicrobial peptide, LEAP-1, LEAP1, HEPC, Hepcidin, HFE2B, PLTR, Putative liver tumor regressor
Target Sequences: NM_021175 NP_066998.1 P81172

Publications (5)

1
Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss. Hao-Han Guo , Lei Xiong , Jin-Xiu Pan, Daehoon Lee, Kevin Liu, Xiao Ren, Bo Wang, Xiao Yang, Shun Cui, Lin Mei, Wen-Cheng Xiong. Bone research. 2021 June;9:31. [Full Text Article] [PubMed:34108442] [PMC:PMC8190093]
2
Low Serum Hepcidin Is Associated With Reduced Short-Term Survival in Adults With Acute Liver Failure. Igor Spivak, Jyoti Arora, Caitlyn Meinzer, Valerie Durkalski-Mauldin, William M Lee, Christian Trautwein, Robert J Fontana, Pavel Strnad, Acute Liver Failure Study Group (ALFSG). Hepatology (Baltimore, Md.). 2019 May;69:2136-2149. [Full Text Article] [PubMed:30582749]
3
Development of a model for anemia of inflammation that is relevant to critical care. Margit Boshuizen, Robin van Bruggen, Sebastian A Zaat, Marcus J Schultz, Eli Aguilera, Ana Motos, Tarek Senussi, Francesco Antonio Idone, Paolo Pelosi, Antonio Torres, Gianluigi Li Bassi, Nicole P Juffermans. Intensive care medicine experimental. 2019 July;7:47. [Full Text Article] [PubMed:31346819] [PMC:PMC6658638]
4
Iron Protein Succinylate in the Management of Iron Deficiency Anemia: A Comparative Study with Ferrous Sulphate at Low and High Therapeutic Doses. Katia Urso, Javier Leal Martínez-Bujanda, Jaime Moscoso Del Prado. Nutrients. 2021 Mar;13:968. [Full Text Article] [PubMed:33802720] [PMC:PMC8002401]
5
Tolerable upper intake level of iron damages the liver of weaned piglets. Haoxuan Ding, Yang Zhao, Xiaonan Yu, Lingjun Chen, Jianan Han, Jie Feng. Journal of animal physiology and animal nutrition. 2021 July;105:668-677. [Full Text Article] [PubMed:33683742] Related Antibodies: LS-C294486.
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Products
Proteins (13)
Over-Expression Lysate (2)
Recombinant (11)
HAMP / Hepcidin (13)
No (13)
GST (1)
GST, N-terminus (2)
His, N-Terminal (2)
His, N-terminus + Human IgG Fc, C-terminus (1)
His-GST (3)
Myc-DDK (Flag) (3)
Bovine (1)
Human (7)
Large Yellow Croaker (1)
Mouse (1)
Pig (1)
Rat (1)
293T Cells (1)
E. coli (8)
HEK 293 Cells (2)
Human (1)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (2)
HAMP / Hepcidin Protein - Eukaryotic Hepcidin By SDS-PAGE
Select
Human
His, N-terminus + Human IgG Fc, C-terminus
34.1kDa
50 µg/$722; 10 µg/$326; 200 µg/$1,325; 1 mg/$2,597; 5 mg/$5,041; 2 mg/$2,788
HAMP / Hepcidin Protein - Recombinant Hepcidin By SDS-PAGE
Select
E. coli
His, N-Terminal
12.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
HAMP / Hepcidin Protein - Recombinant Hepcidin By SDS-PAGE
Select
E. coli
His, N-Terminal
12.6 kDa
10 µg/$274; 50 µg/$400; 100 µg/$637; 200 µg/$797; 1 mg/$1,870; 500 µg/$1,424; 5 mg/$2,832; 2 mg/$2,053
HAMP / Hepcidin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
None
1 mg/$1,568; 100 µg/$534; 20 µg/$422
HAMP / Hepcidin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
6.9 kDa
20 µg/$150
HAMP / Hepcidin Protein - Recombinant Hepcidin By SDS-PAGE
Select
E. coli
His-GST
33.5 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
HAMP / Hepcidin Protein - Recombinant Hepcidin By SDS-PAGE
Select
E. coli
His-GST
38.7 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
HAMP / Hepcidin Protein - Recombinant Hepcidin By SDS-PAGE
Select
E. coli
His-GST
36.0 kDa
10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309
HAMP / Hepcidin Protein - 12.5% SDS-PAGE of human HAMP stained with Coomassie Blue
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Wheat Germ Extract
GST
32.34 kDa
10 µg/$479; 25 µg/$670
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E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
HAMP / Hepcidin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
6.9 kDa
100 µg/$494
Select
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
29.2 kDa
10 µg/$344; 50 µg/$584
HAMP / Hepcidin Protein - Purified recombinant protein HAMP was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
6.9 kDa
20 µg/$1,107
Viewing 1-13 of 13 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).