Hamartin / TSC1

tuberous sclerosis 1

Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kD isoform of TSC1 has been shown to exist but its function is unknown.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

Hamartin / TSC1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human Hamartin / TSC1 Protein (Recombinant GST, N-terminus) (aa166-274) - LS-G60426

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Hamartin / TSC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80204

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

129.6 kDa

Price:

20 µg/$215

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Hamartin / TSC1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99017

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

129.6 kDa

Price:

100 µg/$710

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