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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Additional Contact Details
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Hairless / HR
hair growth associated
Hairless / HR is a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | hair growth associated |
| Synonyms: | HR, ALUNC, Hairless, Hairless homolog (mouse), HSA277165, MUHH, Protein hairless, AU, Hair growth associated, Hairless (mouse) homolog, MUHH1 |
| Target Sequences: | NM_018411 NP_060881.2 O43593 |
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