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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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HACE1

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Gene Name: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Synonyms: HACE1, HACE, KIAA1320
Target Sequences: AB037741 Q8IYU2 Q8IYU2


Select
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
200µg   $365.00
Select
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
FITC Conjugated
100µg   $315.00
Select
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
Biotin Conjugated
100µg   $305.00
Select
Rabbit Polyclonal (IgG) to Human HACE1
Human
ELISA, IF, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal to Human HACE1
Xenopus, Mouse, Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   1mg/ml   $355.00
HACE1 Antibody - 1:100 staining human brain carcinoma tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
HACE1 Antibody - Immunohistochemistry image at a dilution of 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human HACE1
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Human
IF, WB
Unconjugated
20µl   $215.00; 50µl   $285.00; 100µl   $295.00; 200µl   $445.00
HACE1 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer using HACE1 Polyclonal Antibody at dilution of 1:50.
Select
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   1.5mg/ml   $205.00; 60µl   1.5mg/ml   $235.00; 120µl   1.5mg/ml   $295.00; 200µl   1.5mg/ml   $395.00
HACE1 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using HACE1 Polyclonal Antibody at dilution of 1:40.
Select
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   1.2mg/ml   $205.00; 60µl   1.2mg/ml   $235.00; 120µl   1.2mg/ml   $295.00; 200µl   1.2mg/ml   $395.00
HACE1 Antibody - All lanes: Anti-HACE1 Antibody at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: 293T/17 whole cell lysate e Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Select
Mouse Monoclonal [clone 1854CT757.66.47] (IgG1,k) to Human HACE1
Human
ELISA, WB
Unconjugated
200µl   $325.00
Select
Rabbit Polyclonal to Human HACE1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   1mg/ml   $305.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI4E10] (IgG2c) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:500)
Select
Mouse Monoclonal [clone OTI4E10] (IgG2c) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI6H8] (IgG2b) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Select
Mouse Monoclonal [clone OTI6H8] (IgG2b) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Mouse Monoclonal (IgG2a,k) to Human HACE1
Human
ELISA
Unconjugated
100µg   $560.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI10D3] (IgG2b) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Select
Mouse Monoclonal [clone OTI10D3] (IgG2b) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI3F5] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Select
Mouse Monoclonal [clone OTI3F5] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI2C7] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Select
Mouse Monoclonal [clone OTI2C7] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
Select
Mouse Monoclonal [clone OTI4F10] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl   1mg/ml   $345.00
HACE1 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Select
Mouse Monoclonal [clone OTI4F10] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg   $395.00
Viewing 1-25 of 43 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).