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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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HACE1

HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Gene Name: HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Synonyms: HACE1, HACE, KIAA1320
Target Sequences: AB037741 Q8IYU2 Q8IYU2

Filtered by: None
Target
HACE1 (44)
Reactivity
Human (44)
Mouse (15)
Rat (12)
Bovine (4)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (8)
Horse (4)
Monkey (8)
Orangutan (3)
Pig (4)
Rabbit (8)
Xenopus (5)
Application
IHC (8)
IHC-P (4)
WB (30)
ELISA (18)
IF (5)
IP (1)
Host
rabbit (20)
mouse (24)
Isotype
IgG (14)
IgG,k (3)
IgG1 (7)
IgG1,k (1)
IgG2a,k (7)
IgG2b (4)
IgG2c (2)
Clonality
monoclonal mc (24)
polyclonal pc (20)
Clone
1854CT757.66.47 (1)
8D3 (3)
OTI10D3 (2)
OTI2C7 (2)
OTI3F5 (2)
OTI4E10 (2)
OTI4F10 (2)
OTI6H8 (2)
Format
AP Conjugated (1)
APC Conjugated (1)
Biotin Conjugated (6)
Carrier-free (6)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (1)
Unconjugated (26)
Epitope
N-Terminus (4)
aa792-841 (4)
Internal (1)
aa420-909 (1)
aa800-900 (1)
Publications
No (44)
Showing 1-25 of 44 results

HACE1 Antibody (clone 8D3) LS-C348205
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
200µg  $365.00

HACE1 Antibody (clone 8D3, FITC) LS-C347809
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
FITC Conjugated
100µg  $315.00

HACE1 Antibody (clone 8D3, Biotin) LS-C347808
Mouse Monoclonal [clone 8D3] (IgG,k) to Human HACE1
Human
ELISA, IF, IHC, IHC-P, WB
Biotin Conjugated
100µg  $305.00

HACE1 Antibody LS-C666064
Rabbit Polyclonal (IgG) to Human HACE1
Human
ELISA, IF, WB
Unconjugated
100µg  $375.00

HACE1 Antibody (Internal) LS-C153439
Rabbit Polyclonal to Human HACE1
Xenopus, Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg 100µl 1mg/ml  $315.00

HACE1 Antibody LS-C807942
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

HACE1 Antibody LS-C673029
Rabbit Polyclonal (IgG) to Human HACE1
Human
ELISA, IHC, IHC-P
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry image at a dilution of 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunohistochemistry image at a dilution of 1:600 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0) . Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4 °C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

HACE1 Antibody LS-C411127
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Human
IF, WB
Unconjugated
50µl  $285.00; 100µl  $295.00; 200µl  $445.00

HACE1 Antibody LS-C403200
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.8mg/ml  $205.00; 60µl 0.8mg/ml  $235.00; 120µl 0.8mg/ml  $295.00; 200µl 0.8mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human gastric cancer using HACE1 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of paraffin-embedded Human gastric cancer using HACE1 Polyclonal Antibody at dilution of 1:40.

HACE1 Antibody LS-C406440
Rabbit Polyclonal (IgG) to Human HACE1
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl 0.5mg/ml  $205.00; 60µl 0.5mg/ml  $235.00; 120µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $395.00
Immunohistochemistry of paraffin-embedded Human ovarian cancer using HACE1 Polyclonal Antibody at dilution of 1:50.
Immunohistochemistry of paraffin-embedded Human ovarian cancer using HACE1 Polyclonal Antibody at dilution of 1:50.

HACE1 Antibody (clone 1854CT757.66.47) LS-C757871
Mouse Monoclonal [clone 1854CT757.66.47] (IgG1,k) to Human HACE1
Human
ELISA, WB
Unconjugated
200µl  $325.00
All lanes: Anti-HACE1 Antibody at 1:2000 dilution Lane 1: 293 whole cell lysate Lane 2: 293T/17 whole cell lysate e Lysates/proteins at 20 µg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

HACE1 Antibody LS-C780177
Rabbit Polyclonal to Human HACE1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

HACE1 Antibody (clone OTI6H8) LS-C795257
Mouse Monoclonal [clone OTI6H8] (IgG2b) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI6H8, Carrier-free) LS-C792338
Mouse Monoclonal [clone OTI6H8] (IgG2b) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Western blot analysis of extracts. (35ug) from 4 different cell lines by using anti-HACE1 monoclonal antibody. (1:500)

HACE1 Antibody (clone OTI4E10) LS-C795247
Mouse Monoclonal [clone OTI4E10] (IgG2c) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI4E10, Carrier-free) LS-C799676
Mouse Monoclonal [clone OTI4E10] (IgG2c) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:500)
Western blot analysis of extracts. (35ug) from 4 different cell lines by using anti-HACE1 monoclonal antibody. (1:500)

HACE1 Antibody (aa800-900) LS-C308172
Mouse Monoclonal (IgG2a,k) to Human HACE1
Human
ELISA
Unconjugated
100µg  $560.00

HACE1 Antibody (clone OTI3F5) LS-C795250
Mouse Monoclonal [clone OTI3F5] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI3F5, Carrier-free) LS-C792331
Mouse Monoclonal [clone OTI3F5] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)

HACE1 Antibody (clone OTI2C7) LS-C795254
Mouse Monoclonal [clone OTI2C7] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI2C7, Carrier-free) LS-C792332
Mouse Monoclonal [clone OTI2C7] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)

HACE1 Antibody (clone OTI4F10) LS-C795251
Mouse Monoclonal [clone OTI4F10] (IgG1) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI4F10, Carrier-free) LS-C792335
Mouse Monoclonal [clone OTI4F10] (IgG1) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)

HACE1 Antibody (clone OTI10D3) LS-C795280
Mouse Monoclonal [clone OTI10D3] (IgG2b) to Human HACE1
Human
WB
Unconjugated
100µl 1mg/ml  $345.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed

HACE1 Antibody (clone OTI10D3, Carrier-free) LS-C792352
Mouse Monoclonal [clone OTI10D3] (IgG2b) to Human HACE1
Human
WB
Unconjugated, Carrier-free
100µg  $395.00
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY HACE1. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-HACE1. (1:2000)
Showing 1-25 of 44 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).