HAAO

3-hydroxyanthranilate 3,4-dioxygenase

3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.

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Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

HAAO (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human HAAO Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64738

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$1,107

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HAAO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114578

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

100 µg/$494

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Human HAAO Protein (Recombinant GST) (Full Length) - LS-G32864

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

59 kDa

Price:

10 µg/$479; 25 µg/$670

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Human HAAO Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74035

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.4 kDa

Price:

20 µg/$150

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Human HAAO Protein (Recombinant GST, N-terminus) (aa97-196) - LS-G62014

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat HAAO Protein (Recombinant His) (Met1-Gly286) - LS-G98405

Source:

E. coli

Tag:

His

Molecular Weight:

34.8 kDa

Price:

100 µg/$982

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Human HAAO Protein (Recombinant His) - LS-G1777

Source:

E. coli

Tag:

His

Price:

50 µg/$361; 250 µg/$739; 10 µg/$261

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