H2AFY / MACROH2A1

H2A histone family, member Y

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

H2AFY / MACROH2A1 (8)

Publications

No (8)

Tag

GST (1)

His, N-Terminal (1)

His-GST (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human H2AFY / MACROH2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89318

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$150

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Human H2AFY / MACROH2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89320

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$150

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Human H2AFY / MACROH2A1 Protein (Recombinant His-GST) (aa109-369) - LS-G16038

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.6 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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Human H2AFY / MACROH2A1 Protein (Recombinant GST) (Full Length) - LS-G31699

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66 kDa

Price:

2 µg/$439

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Human H2AFY / MACROH2A1 Protein (Recombinant His, N-Terminal) - LS-G144792

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

39.3 kDa

Price:

50 µg/$419

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H2AFY / MACROH2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

100 µg/$494

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Human H2AFY / MACROH2A1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71254

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$1,107

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H2AFY / MACROH2A1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120267

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

100 µg/$494

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